Diastereoselective synthesis of phosphonato esters by reaction between triphenylphosphite and acetylenic esters in the presence of NH-acid compounds

Diastereoselective Synthesis of Stable Phosphorus Yields by a Three-Component Reaction between Ph3P and Acetylenic Esters in the Presence of Hydrazine Derivatives

In this work, stable crystalline phosphorus yields are obtained in good yields from the 1:1:1 addition reactions between hydrazine derivatives and dialkyl acetylenedicarboxylates in the presence of triphenylphosphine at room temperature in dichloromethane. This synthetic method has merits of high yields, mild reaction conditions, and simple experimental and work-up conditions. The obtained yiel...

Chemoselective Reaction Between 5,5-Diarylhydantoins and Acetylenic Esters in the Presence of Trialkyl Phosphite

The adducts produced in the reaction between trialkyl phosphites and acetylenic esters were trapped by hydantoins to produce highly functionalized dialkyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl) succinate in good yields.

diastereoselective synthesis of stable phosphorus yields by a three-component reaction between ph3p and acetylenic esters in the presence of hydrazine derivatives

chemoselective reaction between 5,5-diarylhydantoins and acetylenic esters in the presence of trialkyl phosphite

the adducts produced in the reaction between trialkyl phosphites and acetylenic esters were trapped by hydantoins to produce highly functionalized dialkyl 2-(2,5-dioxo-4,4-diphenylimidazolidin-1-yl) succinate in good yields.

Synthesis of Pyrrole Phosphonate Esters: Emphasis on Pyrrole NH Acids and Dialkylacetylenic Esters Substitution

Reaction of dialkyl acetylenedicarboxylates 1a-c andpyrrole derivatives 2a-e in the presence of triphenylphosphite (TPP) was investigated and the effect of the pyrrole substitution was established. Diastereoselectivity is observed with pyrroles, 2a,b, yieldingphosphonate ester derivatives 3a-f and 4,and their relative configuration is determined by 1H/13C and 31</...